Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/3749
Title: Variability in the relationship between serum creatinine and creatinine clearance in hypertensives and normotensives with normal renal function
Authors: Kadiri, S
Ajayi, SO
Keywords: Hypertension
Creatinine
Glomerular filtration rate.
Variability
Issue Date: 2000
Publisher: COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN, NIGERIA
Citation: Afr. J. Med. Med. Sci. (2000) 29, 93 -96
Abstract: Variabilities exist in the relationship between serum creatinine (Se-C) and creatinine clearance (CCr) due to the influences of age, muscle mass and gender on creatinine production. We studied this variability in a group of hypertensives (n = 62, 30 males, age 44 ± 7 years) and normotensives (n = 90, 47 male, age 42 ± 1 0 years) with normal renal function (Se-C< 0.01) and females (84 ± 19mL/min Vs 96 ± 19mL/min, P < 0.01). Crude CCr was significantly higher in men than women (P < 0.05) in the whole group but not significantly in the normotensive or hypertensive subgroups. After adjustment, the differences diminished and became insignificant in the whole group. Some subgroups had identical mean Se-C values but different adjusted CCr. A particular Se-C value did not always indicate a particular CCr. Adjustment of CCr to 1.73 m 2 BSA reduced the variability between Se-C and CCr and the difference between the genders. CCr showed significant difference in renal function between subgroups where Se-C did not.
Description: Article
URI: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/3749
ISSN: 1116-4077
Appears in Collections:African Journal of Medicine and Medical Sciences

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