Comparative Bioavailability Studies on Brands of Diazepam Tablets

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Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1844

Title:	Comparative Bioavailability Studies on Brands of Diazepam Tablets
Authors:	OGUNBONA, F. A ADEDOYIN, P. A OLANIYI, A. A
Keywords:	Diazepam tablets Valium Bioequivalence studies Oxazepam
Issue Date:	1985
Publisher:	BLACKWELL SCIENTIFIC PUBLICATIONS
Citation:	Afr. J. Med. med. Sci. (1985) 14. 21-25.
Abstract:	The chemical and biological equivalence of two brands of diazepam tablets marketed in Nigeria were compared to that of Valium (Roche) tablets. The tablets used were Relanium (Polfa) and Tropium (Biode). Bioequivalence studies of the brands were carried out on nine healthy volunteers by monitoring the cumulative diazepam excreted as oxazepam (both free and conjugated) in urine over 48 h. The bioequivalence of Relanium was found not to be significantly different from that of Valium while that of Tropium was significantly different from that of Valium (P < 0.05). The results of the investigation showed that the drug products were all chemical equivalents but not biological equivalents.
Description:	Article
URI:	http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1844
ISSN:	1116-4077
Appears in Collections:	African Journal of Medicine and Medical Sciences

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