Biochemical nutritional parameters and anthropometry measurements in Nigerian pulmonary tuberculos patients before and during chemotherapy

Abstract

Background: Epidemiological studies have demonstrated an overlap between malnutrition and tuberculosis (TB) in most developing countries, but reports of changes in nutritional status throughout TB treatment arc scarce. The objective of this study was to determine the nutritional status of pulmonary TB patients before and during anti TB chemotherapy. Materials and methods: This study comprised of sixty eight (68) participants, twenty-four (24) multi drug-resistant TB (MDR-TB) patients, twenty-four (24) drug-sensitive TB patients(DS-TB) and 20 non TB apparently healthy individuals. TB patients were followed-up throughout 6 months of anti-TB chemotherapy. Anthropometric measurements; mid upper arm circumference(MUAC), weight, body mass index(BMI), percentage body fat(PBF), fat mass index(FMI), fat-free mass index(FFMI), waist circumference(WC), hip circumference(HC), waist hip ratio(WHR), and plasma proteins(totaI protein, transferrin, retinol binding protein-RBP, pre-albumin and albumin) concentrations were determined. Results: Under nutrition (BMI