Thyroid function in haemodialysed patients of Gassim, Saudi Arabia: TRH stimulation

Abstract

To study the hypophysical-pituitary-thyroid axis in Saudi patients on (RDT), 200 units of T R H were given intravenously predialysis to each of 21 such subjects. As expected (TSH) rose promptly within 3 0 minute s followed by a gentle decline at 60 minutes. A more gentle rise was also noted in T3 which continued for the 60 minutes of observation. Rather unexpectedly, T4 level was noted to show a reciprocal decline, to our knowledge , this pattern has not been defined in literature. In 12 patients (GH) was noted to rise promptly within 30 minutes followed by a gentle decline at 60 minutes. (LH) and (FSH) did not follow any definite pattern as observed for T 3 and T 4 . Since the oral preparation of T R H is now available, c a n (TRH ) be effectively used to treat renal dwarfism?