Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2434
Title: GRANULOMA FORMATION AROUND EXOGENOUS EGGS OF SCHISTOSOMA MANSONI AND SCHISTOSOMA JAPONICUM IN MICE
Authors: EDUNGBOLA, L.D.
CHA, Y.N.
BUEDING, E.
SCHILLER, E.L.
Keywords: surgical injection
infections
Hepatic
studies
Issue Date: 1982
Publisher: BLACKWELL SCIENTIFIC PUBLICATIONS
Citation: Afr. J. Med. med. Sci. (1982) 11.75-79
Abstract: Hepatic granulomata which were qualitatively and quantitatively similar to those seen in infections established with cercariae were induced by surgical injection of exogenous eggs of Schistosoma mansoni and Schistosoma japonicum via the mesenteric veins of previously unexposed albino mice. Thereafter, their comparative histopathologic studies were made. The maximum mean sizes of granulomata were attained on Day 32 with viable eggs of these parasite species. Although S. mansoni eggs produced significantly larger lesions (368-4 ± 21-5 pm) than eggs of S. japonicum (205-8 ± 18-6 Jim) at the peak period, the difference in the mean granulomal size showed no correlation with cither the time of onset or the severity of pathologic changes produced. Thus, eggs of 5. japonicum with smaller granulomata, evoked pathologic changes which were earlier in onset and more severe than those produced by the same quantity of 5. mansoni eggs. Since the most obvious variables (the quantity of eggs, the sequence of their arrival in the liver, the timing of observation, and the strain of experimental animals) were controlled, it was concluded that the most severe and fatal effects produced by eggs of S. japonicum, as previously suggested, are largely due to differences in the cytotoxic and antigenic peculiarities of this species
Description: ARTICLE
URI: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2434
ISSN: 1116-4077
Appears in Collections:African Journal of Medicine and Medical Sciences

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