Effect of stress conditions on the course of trophozoite-induced Plasmodium yoelii nigeriensis in mice recently cured of a previous infection

Abstract

The effects of stress conditions on the course of trophozoite-induced Plasmodium yoelii nigeriensis in mice recently treated for a previous infection was studied. It was found that when the mice were infected with up to 5943 parasites within 6 days of treating a previous infection, no patent infection was recorded. However, an inoculum of 7924 parasites induced parasitaemia, with a long period of prepatency and a short course of infection before the parasites died out. None of the mice re-infecled with the parasite, and maintained at different temperatures. was positive during the period of the experiment.