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Title: | Lipid peroxidation in Nigerians affected with haematological malignancies |
Authors: | Akinlolu, A Akingbola, T Salau, B |
Keywords: | Lipid peroxidation haematological cancer chronic myeloid leukemia |
Issue Date: | Dec-2012 |
Publisher: | College of Medicine University of Ibadan |
Citation: | Afr. J Med med. Sci. (2012) 41, Suppl. 145-148 |
Abstract: | This stud y investigate d Lipid peroxidation status in twent y Nigerians; fiv e (5) healthy subjects and 15 (fifteen ) Haematologica l cancer patients; 5 affected wit h Chroni c Myeloi d leukaemia (CML), 5 (five) with Non-Hodgkin' s Lymphoma and 5 (five) with Multiple Myeloma . Consents wer e sought and received from a ll participants used in the study. lOmls of blood sample s wer e collected in lithium heparin bottles from a l l subject s use d in t h e study . Fre e plasma Malondialdehyd e (MDA ) quantification was used to asses s lipi d peroxidatio n in all subjects. MDA levels wer e increase d in C M L and Non-Hodgkin Lymphoma patient s compare d with that of control subjects at P<0.001 . However , a decreased non-significant free plasm a M D A level wa s observed in multiple myeloma patient s compare d with control subjects. Increase in lipi d peroxidatio n status in Nigerians affected with Haematologica l malignancies may be associated with a d y sregulatio n o f antioxidan t system. Lipid peroxidatio n statu s could be used as clinical clue for diagnosis , prognosis and treatment of patients affected wit h haematologica l malignancies. |
Description: | Article |
URI: | http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2005 |
ISSN: | 1116-4077 |
Appears in Collections: | African Journal of Medicine and Medical Sciences |
Files in This Item:
File | Description | Size | Format | |
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Akinlolu et al_Lipid_2012.pdf | Article | 8.28 MB | Adobe PDF | View/Open |
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