Please use this identifier to cite or link to this item:
http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1976
Title: | The role of neutrophils in acute and chronic inflammation in rats |
Authors: | EZEAMUZIE, I. C. NJOKU, A. C. |
Keywords: | Neutropenia Rats Histamine Oedema |
Issue Date: | 1992 |
Publisher: | Spectrum Books Limited |
Citation: | Afr. J. Med. med. Sci. (1992) 21(2): 23-28 |
Abstract: | The effect of neutropenia on acute and chronic inflammatory oedema in rats was assessed using histamine, carrageenan and Freund's complete adjuvant as inducers. Neutropenia (about 85% reduction in peripheral blood neutrophil count) was induced with intraperitoneal administration of 2.5 mg/kg methotrexate for three consecutive days. Acute paw oedemas induced with carrageenan and Freund's complete adjuvant, but not that induced by histamine, were significantly decreased in neutropenic animals compared with controls. In adjuvant-induced chronic knee swelling (Adjuvant arthritis), neutropenia produced small, statistically non-significant, suppressive effect. In contrast, it significantly suppressed adjuvant-induced chronic paw swelling, although suppression was observed only in the late phase component of the swelling. The results suggest that neutrophils are involved in certain acute and chronic inflammatory responses but not in others. |
URI: | http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1976 |
ISSN: | 1116-4077 |
Appears in Collections: | African Journal of Medicine and Medical Sciences |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Ezeamuzie_Njoku_Role_1992.pdf | Article | 10.98 MB | Adobe PDF | View/Open |
Items in COMUI (ADHL) are protected by copyright, with all rights reserved, unless otherwise indicated.