Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1746
Title: Breath hydrogen excretion or plasma acetate levels during the lactulose tolerance test?
Authors: Akanji, A.O
Hockaday, D.R
Keywords: Acetate
Hydrogen
Lactulose
Plasma
Issue Date: 1991
Publisher: Blackwell Scientific Publications
Citation: Afr J. Med. Med. Sci. (1991) 20. 101-105.
Abstract: Since both acetate and hydrogen are produced by colonic bacterial fermentation, the clinical utility of the measurement of either parameter in nine subjects for the lactulose tolerance test was tested. The fasting plasma acetate concentration (mean ± s.d., mmol/l) of 0.11 ± 0.06 increased to peak levels between 150 min (0.23 ± 0.12) and 180 min (0.23 ± 0.09), both P < 0.01, after ingesting 20 g lactulose. In one subject with previous gastrectomy and intestinal hurry, the peak was at 30 min. Mean post lactulose acetate levels (0.21 ± 0.09) were higher than fasting levels (P < 0.03). Breath hydrogen excretion exhibited a similar trend. Indeed, a significant correlation (rN 0.39, P < 0.01) was demonstrated between the acetate and hydrogen values. It is therefore concluded that patients for the lactulose breath test show fairly similar changes in plasma acetate and breath hydrogen excretion after lactulose ingestion. Either measurement could thus be used in assessing colonic fermentation in humans.
URI: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1746
ISSN: 1116-4077
Appears in Collections:African Journal of Medicine and Medical Sciences

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