Inhibition of erythrocyte membrane Ca 2 + -pumping ATPase of hypertensive humans by nifedipine, a calcium entry blocker

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Title:	Inhibition of erythrocyte membrane Ca 2 + -pumping ATPase of hypertensive humans by nifedipine, a calcium entry blocker
Authors:	Olorunsogo, O. O Onatola, O. O Lawal, S. O. A Bababunmi, E. A Falase, A. O Okunade, W. G
Keywords:	Nifedipine Hypertension Erythrocyte Calcium
Issue Date:	1991
Publisher:	Blackwell Scientific Publications
Series/Report no.:	Afr. J. Med. med. sci.1991:20;61-65;
Abstract:	Nifedipine, a 1,4-dihydropyridine antihypertensive drug, inhibited the basal activity of erythrocyte C a 2 +, Mg 2 + -ATPase of hypertensive individuals in a concentration-dependent manner. About 5 0 % inhibition was obtained at nifedipine concentrations ^ 300 µᴍ. The extent of inhibition of the ATPase action was increased in the presence of calmodulin. Maximal inhibition at 400 µᴍ was 76%. Furthermore, the activity of the partially trypsinized enzyme was inhibited by about 5 0 % by 300 µᴍ nifedipine. Similar results were obtained with membranes from normotensive individuals. These findings suggest that nifedipine could prevent C a 2 + -pumping by the erythrocyte C a 2 +, M g 2 + -ATPase
URI:	http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1733
ISSN:	1116-4077
Appears in Collections:	African Journal of Medicine and Medical Sciences

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