Hypoglycaemic activity of a , a trehaIose-6-phosphate

Abstract

a-a-trehalose-6-phosphate, synthesized by Oke was screened for hypoglycemic activity. Alloxan-induced diabetic albino rats and fasted-rabbits were used in the study. The inhibitor) activity of trehalose-6-phosphate on trehalase was also assayed. The study shows that a-a - trehalose-6-phosphate is a glucose analogue with potent anti-hyperglcaemic activity as shown by its hypoglycemic response in fasted rabbits. The ability of a-a-trehalosc-6-phosphate to attenuate the diabetic toxicity in alloxan-induced diabetic rats confirmed its potent anti-diabetic activity. The mechanism of action of this synthesized compound may be linked with its ability to inhibit trehalase, and increase the activity of the superoxidase dimutase present in the β-cells of the alloxan-diabetic rats and also being a glucose analogue according to Puls principle, a-a-trehalose-6-phosphate is able to influence the intermediate metabolism of carbohydrate