Hypoglycaemic activity of a , a trehaIose-6-phosphate

Oke, J.M; Watt, R.A

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DC Field	Value	Language
dc.contributor.author	Oke, J.M	-
dc.contributor.author	Watt, R.A	-
dc.date.accessioned	2024-10-09T10:45:22Z	-
dc.date.available	2024-10-09T10:45:22Z	-
dc.date.issued	1998	-
dc.identifier.citation	Afr. J. Med. med. Sci. (1998) 28, 219-233	en_US
dc.identifier.issn	1116-4077	-
dc.identifier.uri	http://adhlui.com.ui.edu.ng/jspui/handle/123456789/3060	-
dc.description	Article	en_US
dc.description.abstract	a-a-trehalose-6-phosphate, synthesized by Oke was screened for hypoglycemic activity. Alloxan-induced diabetic albino rats and fasted-rabbits were used in the study. The inhibitor) activity of trehalose-6-phosphate on trehalase was also assayed. The study shows that a-a - trehalose-6-phosphate is a glucose analogue with potent anti-hyperglcaemic activity as shown by its hypoglycemic response in fasted rabbits. The ability of a-a-trehalosc-6-phosphate to attenuate the diabetic toxicity in alloxan-induced diabetic rats confirmed its potent anti-diabetic activity. The mechanism of action of this synthesized compound may be linked with its ability to inhibit trehalase, and increase the activity of the superoxidase dimutase present in the β-cells of the alloxan-diabetic rats and also being a glucose analogue according to Puls principle, a-a-trehalose-6-phosphate is able to influence the intermediate metabolism of carbohydrate	en_US
dc.description.sponsorship	COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN, NIGERIA	en_US
dc.language.iso	en	en_US
dc.publisher	COLLEGE OF MEDICINE, UNIVERSITY OF IBADAN, NIGERIA	en_US
dc.subject	a-a-trehalose-6-phosphate	en_US
dc.subject	Fasted-rabbits trehalase	en_US
dc.subject	Anti-diabetic	en_US
dc.subject	Alloxan-induced-diabetic-rats	en_US
dc.title	Hypoglycaemic activity of a , a trehaIose-6-phosphate	en_US
dc.type	Article	en_US
Appears in Collections:	African Journal of Medicine and Medical Sciences

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