Effects of aspirin (acetylsalicylic acid) and Cataflam (potassium diclofenac) on some biochemical parameters in rats

Abstract

The effects of graded doses of aspirin (acetylsalicylic acid) and cataflam (potassium diclofenac) on serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, 5'Nuclcotidase, methaemoglobin, total and congaed bilinibin were investigated in wistar rats. Results showed a significant increase (P < 0.05) in the levels of alanine aminotransferase, aspartate amino transferase, methaemoglobin, total and conjugated bilirubin upon treatment of animals with both drugs. Aspirin significantly decreased (P < 0.05, P < 0.00) the activity of alkaline phsophatase but increased the activity of 5'ucleotidasc while cataflam significantly increased the activity of alkaline phosphatase (P < 0.001) and 5'nuclctodase (P < 0.05). These effects were however dose dependent and the biochemical implications of these results are discussed