Effects of metaraminol, insulin and trasylol on the responses to haemorrhage in dogs

Abstract

The effect of addition of metaraminol, insulin and triazolyl to fluid replacement with glucose-saline, on the responses to hemorrhage (30% of blood volume) in dogs, was investigated. Addition of metaraminol significantly increased the blood sugar and lactate responses to hemorrhage; the lactate-pyruvate (L/P) ratio, plasma phosphate and free fatty acid (FFA) levels were also significantly increased. A delayed hypotension was observed. Responses to hemorrhage during infusion of glucose-saline + insulin showed reduced blood sugar, blood lactate, pyruvate, and L/P ratios, plasma inorganic phosphate and FFA were diminished while, mean arterial blood pressure (MABP) changes were significantly higher than the glucose-saline group. Infusion of triazolyl in glucose-saline did not significantly affect the blood sugar, lactate, and pyruvate responses and the L/P ratio. Plasma phosphate response was also like the control group. The responses of plasma FFA and of MABP in this group were significantly higher; than the glucose-saline group. The mechanisms of these effects and the significance of these results are discussed