Evaluation of anti-ulcerogenic and ulcer-healing activities of nevirapine in rats

Abstract

Background: Nevirapine is a very potent antirctrovira l drug frequently used in the management of Human Immunodeficiency Virus (HIV). Opportunistic pathologies in HIV/AIDS patients include gastric ulcer and gastrointestinal haemorrhage. Hence, the impact of nevirapine on induced gastric ulcer was studied using Wistar rats. Methods: Anti-ulcer activity of nevirapine was evaluated using cold restraint stress-induced, ethanol-induced and pylorus ligation-induced gastric ulcer models for acute ulceration; and acetic acid induced ulcer model for the chronic ulceration in Wistar rats. Results: Nevirapine (9mg/kg, 18mg/kg and 36mg/ kg ) showed significant (P<0.05) reduction in ulcer severity score and ulcer index as compared to the control in the models, with corresponding increase in percentage inhibition. Histopathological studies showed that nevirapine has a positive effect on the healing of gastric ulcer in the groups treated with the nevirapine compared with the control. The induced ulcers healed up in all the groups administered with nevirapine compared to what was found in the omeprazole group where manifestations of ulcer like inflammatory cells infiltration is still present. Conclusion: Nevirapine may possess highly therapeutic effect in the treatment and prevention of gastrointestinal complications that might come with the presence of HIV virus in patients