Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2565
Title: Isolation of an anti-tumour terpenoid from stem bark of Spondianthus preussii var. preussii Engl.
Authors: Abo, KA
Kinghorn, AD
Keywords: Anti-tumour activity
Euphorbiaceae
Spondianthus preussii
Hydroxylupenoic acid
Issue Date: Mar-2003
Publisher: Spectrum Books Limited
Citation: Afr. J. Med. med Sci (2003) 32; 179-182
Abstract: We report a biologically monitored phytochemieal separation of stem bark of Spondianthus preussii var. preussii against a panel of human cancer cell lines in vitro and the P-388 murine lymphocytic leukemia cells in culture. An ethylacetate extract of the stem bark exhibited selective cytotoxicity against human melanoma (EDJ0 = lO.Oug/ml). Further activity-guided fractionation of the ethylacetat e extract by flash chromatography and subsequent purification on preparative thin layer chromatography led to the identification of a lupane-typc triterpene, 3(3-hydroxy-20(29) - lupenoic acid, by spectroscopic methods. This is the first report of the occurrence of this compound in S. preussii var. preussii. It is also the first time this triterpene is being shown to exhibit in vitro anti-tumor activity against human melanoma (EDJ0 = 2.4ug/ml). This compound could be a promising bioactive natural product since it has been previously reported to exhibit a range of biological activities including in vivo and in vitro antiplasmodial activity and it is not toxic.
Description: ARTICLE
URI: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2565
ISSN: 1116-4077
Appears in Collections:African Journal of Medicine and Medical Sciences

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