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dc.contributor.authorDAGOGO-JACK, SAM-
dc.date.accessioned2024-07-22T10:27:25Z-
dc.date.available2024-07-22T10:27:25Z-
dc.date.issued1995-
dc.identifier.citationAfr.J. MedmedSci. (1995) 24, 211-217en_US
dc.identifier.issn1116-4077-
dc.identifier.urihttp://adhlui.com.ui.edu.ng/jspui/handle/123456789/2267-
dc.descriptionArticleen_US
dc.description.abstractSeveral cytokines and growth factors together with their binding proteins and/or receptors arc being increasingly detected in mammalian thyroid tissue. These include epidermal growth factor, insulin-like growth factors, transforming growth factors, fibroblast growth factor, intcrlcukins, interferons, and tumour necrosis factor-alpha. Their exact role in relation to thyroid regulation has not been fully elucidated but it is clear that many of these peptide regulatory factors arc mitogcnic for cultured thyrocytes. Recent evidence suggests that some thyroid cancers and benign goiters over-express receptors for a number of these growth factors. Transforming growth factor-beta is unique for its dominant anti-proliferative effect on thyrocytes concurrently exposed to potent thyroid mitogens. The mammalian thyroid cell is clearly a source as well as target of myriad polypeptide factors that prolwbly co-regulate its normal growth and differentiation. Aberrant expression of these growth factors or their receptors might be a factor in the development of goiter.en_US
dc.description.sponsorshipCollege of Medicineen_US
dc.language.isoenen_US
dc.publisherSpectrum Books Limiteden_US
dc.subjectGoitrogenesisen_US
dc.subjectCytokinesen_US
dc.subjectAberranten_US
dc.subjectinsulinen_US
dc.titleA new understanding of goitrogenesis: role of cytokines in the regulation of normal and aberrant thyroid growthen_US
dc.typeArticleen_US
Appears in Collections:African Journal of Medicine and Medical Sciences

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