Effects of calcium channel blockers on nicotine-induced hyperglycemia in the rat

Alada, A.R.A

COMUI (ADHL)

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Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2223

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DC Field	Value	Language
dc.contributor.author	Alada, A.R.A	-
dc.date.accessioned	2024-07-18T11:55:08Z	-
dc.date.available	2024-07-18T11:55:08Z	-
dc.date.issued	2001	-
dc.identifier.citation	Afr. J. Med. Med. Sci. (2001) 30: 57-59	en_US
dc.identifier.issn	1116-4077	-
dc.identifier.uri	http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2223	-
dc.description	Article	en_US
dc.description.abstract	Effects of nifedipine and verapamil on nicotine-induced h>perglycemia were studied in fasted, anesthetized male rats. Blood glucose was measured using the glucose oxidase method. Nifedipine (0.05-0.20 mg/kgi.p.) significantly reduced nicotine induced hyperglycemia in a dose - dependent manner. While lower doses (0.1.0-1.0 mg/kg i.p) of verapamil did not effect nicotine-induced hyperglycemia, higher doses 95.0 - 10 mg/kg i.p) of verapamil caused significant reduction but did not abolish it. Both nifedipine and verapamil had no significant effect on the basal blood glucose levels at any dose used. These results seem to suggest that the reduction in nicotine - induced hyperglycemia is related to inhibition of some of the processes by which nicotine induced hyperglycemia.	en_US
dc.description.sponsorship	COLLEGE OF MEDICINE	en_US
dc.language.iso	en	en_US
dc.publisher	COLLEGE OF MEDICINE	en_US
dc.subject	Verapamil	en_US
dc.subject	nifedipine	en_US
dc.subject	nicotine-induced hyperglycemia	en_US
dc.subject	rat	en_US
dc.title	Effects of calcium channel blockers on nicotine-induced hyperglycemia in the rat	en_US
dc.type	Article	en_US
Appears in Collections:	African Journal of Medicine and Medical Sciences

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