Effects of drug-induced hyperuricaemia on renal function in nigeria with pulmonary tuberculosis

Abstract

ome anti-tuberculosis chemotherapeutic agents have been established as causing hyperuricaemia. Hyperuricaemia in turn causes renal damage. This study therefore aims at establishing the effect of anti-tuberculosis drugs-induced hyperuricaemia on renal function of the patients. Fifty patients with newly diagnosed pulmonary tuberculosis with mean age of 36.8 years (SD 13.69) consisting of 14 females and 17 males were longitudinally studied each for 6 months to determine the effect of drug-induced hyperuricaemia on their renal function. The Biochemical indices determined included serum urate level, serum creatinine level, and creatinine clearance of newly diagnosed patient with tuberculosis, before and during treatment with anti-tuberculosis therapy. Serum urate level revealed that 16(51.6%) and 15 (48.4%) of the patients were hyperuricaemic at the end of the first and second months of anti-tuberculosis therapy There was no significant difference in the mean serum creatinine level of the control group 96 ^mol/L when compared with both thepre-treat value 89fimol/L (P> 0.25) as well as the value at the end of the sixth month of treatment 91 jimo!/ L (P> 0.40). However, there was a statistically significant difference in the mean creatinine clearance of the control group 102m!/min/1.73m2 when compared with the patient's mean pre-treatment value (89 ml/min/l .73m2) P< 0.05. Also the mean creatinine clearance increased to (103 ml/min/ 1.73m ) by the end of the 6th month of treatment, a value ,s statistically significant when compared with the pretreatment value of (89 ml/min/l .73m-) P< 0.05. We submit as follows; that pulmonary tuberculosis as a disease with significam impairment of renal function; despite the associ1 e rug-induced hyperuricaemia recorded during the treatment, renal function steadily improved with the treatment of v,rnary tu^crcu'os's to the extent that comparable values ludpCftmrr W3S obtaincd at !hc cnd of treatment. We conk'lth t CrC °rC ^at ^ruS"'n<*uccd hyperuricaemia associated , Cat™?nt Pl,'nionary tuberculosis has no detectable >vc effcct on renal function of the patient