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http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1962
Title: | Nigerian bonny light crude oil induces irreversible reproductive toxicity in adult male rats |
Authors: | ADEDARA, I. A. EBOKAIWE, A. P. EHWERHEMUEPHA, T. TEBEREN, R. FAROMBI, E. O. |
Keywords: | Bonny Light Crude Oil (BLCO) Infertility Sperm Fertility Rats |
Issue Date: | Dec-2012 |
Publisher: | College of Medicine University of Ibadan |
Citation: | Afr. J. Med. med. Sci. (2012) 41(Suppl): 65-74 |
Abstract: | Background: The reversibility of reproductive toxicity induced by the Nigerian Bonny light crude oil (BLCO) was investigated in rats. Method: Adult male Wistar rats were orally treated with BLCO at 0, 50, 100 and 200mg kg for 21days. One-half of the rats were sacrificed on day 22 while the remaining one-half stayed additional 21 days without treatment. Results: While sperm quality was compromised in dose-dependent manner, testis histopathology was only evident at 200mg kg 1 after 21days. BLCO significantly decreased activities of superoxide dismutase, catalase and glucose-6-phosphate dehydrogenase but markedly elevated gamma glutamyl transferase and glutathione S-transferase activities as well as malondialdehyde. hydrogen peroxide and glutathione levels in both testes and sperm. Most of the above-mentioned parameters were consistent in animals from withdrawal experiment. Conclusion: Taken together, BLCO exposure impaired fertility via increased oxidative stress and was not reversible upon withdrawal of treatment within the time course of investigation in male rats. BLCO exposure poses a risk for impaired fertility and its contribution to infertility in the Nigerian male population may not be excluded. |
Description: | Article |
URI: | http://adhlui.com.ui.edu.ng/jspui/handle/123456789/1962 |
ISSN: | 1116-4077 |
Appears in Collections: | African Journal of Medicine and Medical Sciences |
Files in This Item:
File | Description | Size | Format | |
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Adedara et al_Nigerian_2012.pdf | Article | 18.34 MB | Adobe PDF | View/Open |
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