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dc.contributor.authorKADIRI, S.-
dc.contributor.authorOSOBAMIRO, O.-
dc.contributor.authorOGUNNIYI, J.-
dc.date.accessioned2023-02-14T11:34:00Z-
dc.date.available2023-02-14T11:34:00Z-
dc.date.issued1993-12-
dc.identifier.citationAfr. J. Med. med. Sci. (1993) 22(4): 29-34en_US
dc.identifier.issn1116-4077-
dc.identifier.urihttp://adhlui.com.ui.edu.ng/jspui/handle/123456789/1950-
dc.descriptionArticleen_US
dc.description.abstractMinimal change disease (MCD), mesangial proliferative glomerulonephritis (MPGN) and focal glomerulosclerosis (FGS) may be indistinguishable at some stage when examined by light microscopy, but MCD in adults has over 80% response rate to prednisolone therapy. In search of MCD, we treated 22 patients with biopsy reported MCD (1 patient), MPGN (15 patients), and FGS (6 patients), out of 84 adult patients with the nephrotic syndrome (NS) seen over 55 months, with prednisolone 60mg daily for 6 weeks (4 patients) or 8 weeks (18 patients). Two patients with MPGN showed partial remissions with proteinuria dropping to 0.8g/24 hours and 1.2g/24 hrs. All the others were non-responsive with proteinuria remaining above 2g/24 hours. Allowing that 20% of patients may not respond to prednisolone, 4 patients may have been missed. It is concluded that MCD as defined by minor glomerular changes and good response to steroids is rare in adult Nigerian patients with the NSen_US
dc.description.sponsorshipCollege of Medicineen_US
dc.language.isoenen_US
dc.publisherSpectrum Books Limiteden_US
dc.subjectNephrotic syndrome (NS)en_US
dc.subjectPrednisoloneen_US
dc.subjectProteinuriaen_US
dc.subjectGlomerular diseaseen_US
dc.titleThe rarity of minimal change disease in Nigerian patients with the nephrotic syndromeen_US
dc.typeArticleen_US
Appears in Collections:African Journal of Medicine and Medical Sciences

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