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dc.contributor.authorMAKINDE, J. M.-
dc.contributor.authorOBIH, P. O.-
dc.date.accessioned2023-01-23T13:47:23Z-
dc.date.available2023-01-23T13:47:23Z-
dc.date.issued1985-
dc.identifier.citationAfr. J. Med med. Sci. (1985) 14, 59-63.en_US
dc.identifier.issn1116-4077-
dc.identifier.urihttp://adhlui.com.ui.edu.ng/jspui/handle/123456789/1837-
dc.descriptionArticleen_US
dc.description.abstractThe leaf extract of Morinda lucida collected in August was administered subcutaneously to albino Swiss mice infected with P, berghei berghei. The schizontocidal activity on early infection was assessed by administering chloroquine (standard) distilled water or Morinda lucida as single daily dose on day 0-3 to infected mice. On day 4 the degree of parasitaemia and percentage was determined in relation to control. Its schizontocidal activity was also observed on an established infection by administering the drugs 72 h after infecting the mice and the degree of parasitaemia was determined daily. The repository action of pyrimethamine was also compared with Morinda lucida. On the early infection, the chloroquine equivalent of Morinda lucida was found to be 1.0 mg/kg. In established infection a daily increase in parasitaemia was observed in control group while the animals that received chloroquine (5 mg/kg) and l/<> dilution of the stock of Morinda lucida extract showed a sharp fall in parasitaemia from the second day of treatment. For the prophylactic test. 1.2 mg/kg of pyrimethamine and /'<> dilution of stock of extract produced SO.5% and 70% chemosupprcssion respectively. It is interesting to note that Morinda lucida leaves extract appears to have schizontocidal and repository effects in mice infected with P. berghei bergheien_US
dc.description.sponsorshipCOLLEGE OF MEDICINEen_US
dc.language.isoenen_US
dc.publisherCOLLEGE OF MEDICINEen_US
dc.subjectMorinda lucidaen_US
dc.subjectInfectionen_US
dc.subjectAlbino Swiss Miceen_US
dc.subjectParasitaemiaen_US
dc.titleScreening of Morinda lucida leaf extract for antimalarial action on Plasmodium berghei berghei in miceen_US
dc.typeArticleen_US
Appears in Collections:African Journal of Medicine and Medical Sciences

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