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dc.contributor.authorOluwole, F.S-
dc.contributor.authorBolarinwa, A.F-
dc.date.accessioned2021-12-09T10:45:37Z-
dc.date.available2021-12-09T10:45:37Z-
dc.date.issued1990-
dc.identifier.citationAfr. J. Med. med. Sci.1990:19. 139-143en_US
dc.identifier.issn1116-4077-
dc.identifier.urihttp://adhlui.com.ui.edu.ng/jspui/handle/123456789/1713-
dc.description.abstractCastration in rats caused a reduction in the degree of ulceration produced by indomethacin. Compared with the normal intact male rats, the value of the castrated rats was highly significant (18.42 ± 0.22 compared with 9.58 ± 0.17) (P < 0.01). However, the normal intact male rats had a greater degree of ulceration than the female rats at the pro-oestrous (2.33 ± 0.13) or oestrous (2.97 ± 0.12) phases. The ovariectomized rats, however, showed no significant reduction ( P > 0.01) in mean ulcer score when compared with the di-oestrous female rats. The mean value of peptic activity was very high in ovariectomized rats while it was reduced in intact female rats. The ovariectomized rats were more prone to ulceration than intact female rats although the susceptibility increased in rats at di-oestrus.en_US
dc.description.sponsorshipCollege of Medicine, University of Ibadanen_US
dc.language.isoenen_US
dc.publisherBlackwell Scientific Publications Oxforden_US
dc.subjectIndomethacinen_US
dc.subjectUlcerationen_US
dc.subjectCastrationen_US
dc.subjectRatsen_US
dc.titleEffects of gonadectomy on indomethacin-induced ulceration and peptic activity in rats.en_US
dc.typeArticleen_US
Appears in Collections:African Journal of Medicine and Medical Sciences

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