Total antioxidant status and lipid peroxidation in HIV-1 infected patients in a rural area of south western Nigeria

Abstract

Total serum antioxidant status (TAS) and lipid peroxidation were evaluated in 62 HIV- 1 seropositive patients before the commencement of antiretroviral drug therapy. Twenty - four (24) age-marched and apparently healthy HIV- 1 seronegative subjects were recruited as control subjects. HIV-1 seropositive patients were classified according to the Centre for Disease Control and Prevention (CDC) Criteria. The mean serum malondialdehyde (MDA) concentrations of 5.58 ± 0.99nmol/ml and 4.2 4 ± 0.80nmol/ml were significantly elevated in HIV- 1 infected patients with CD4 + count of 500 lym/mm3 was not significant (P>0.05). In the intra groups comparison serum concentration of MDA were significantly elevated when compared with each other (P<0.001). The mean serum total antioxidant status (TAS) of 1.3 0 ±0.11 mmol/L, 1.12 ±0.2 4 mmol/ L and 0.9 5 ± 0.17mmol/ L of HIV- 1 seropositive patients with CD4 + count of >50 0 lym/mm3,200-49 9 lym/mm3 and <200lym/mm 3 respectively were significantly reduced compared with 1.69 ± 0.23mmol/L for the control group (P<0.001). Similarly, in the intra groups comparison, serum concentration of TAS were significantly reduced when compared with each other (P<0.001).