EFFECT OF COW'S URINE CONCOCTION ON BLOOD FLOW, OXYGEN CONSUMPTION AND GLUCOSE UPTAKE IN THE CANINE SMALL INTESTINE

Abstract

The effects of cow's urine concoction (CUC) on blood pressure, blood flow, vascular resistance, oxygen consumption and glucose uptake in the canine small intestine were studied in normal (untreated) dogs and in dogs pre-treated with propranolol (0.5 mg/kg). Cow's urine concoction was administered as a slow intravenous infusion for 10 min and 1 hr recovery period was allowed. The results showed that CUC caused a significant increase in blood pressure and blood flow during infusion. This was followed by post-infusion hypotension and reduction in blood flow to below resting values. The hypertensive and flow increase responses to CUC were reduced in propranolol-treated animals. Also, blood flow decrease was significantly lower in the propranolol-treated animals. Vascular resistance increased in the first 5 min of infusion in the untreated animals, but fell significantly to below resting level throughout the recovery period. The increase in vascular resistance during CUC infusion was abolished by propranolol. Vascular resistance, though lower than in the untreated animals early in the recovery period, had returned to control level at the end of 1 hr recovery period