FIELD TRIALS OF PYRANTEL PAMOATE (COMBANTRIN) IN ASCARIS, HOOKWORM AND TRICHURIS INFECTIONS

Abstract

In a trial involving 185 school children, pyrantel pamoate (Combantrin) at a dose of 20 mg/kg body weight for 1-3 days was found to be very effective against the As car is and moderately effective against the hookworm, with mean cure rates ranging from 93-3-96-7% and 53-3-73-3% respectively. No apparent action against the Trichuris was detected, a mean cure rate of between 34-2 and 46-1% being only slightly, but not significantly, better than the 33-8% cure for a placebo-treated control group Snglc and multiple doses of the suspension 'ablet formulations of the drug were well tolerated From the series of randomized and v. strolled trials conducted, we recommend that, in this area, the appropriate dose of the drug to use for treating ascariasis is 10 mg/kg per day for 1 day, and for infections which include hookworm, 20 mg/kg per day for 3 days