Changes in endoplasmic reticulum associated with P-naphthoflavone-inducible cytochrome P450 in murine liver, a quantitative analysis

Abstract

Cytochrome P450s arc found associated with membranes of endoplasmic reticulum where they catalyse the oxidation and biotransformation of a wide range of substances. It is therefore expected that their induction and catalytic activities would con-elate with the ultrastructure of the cell. In this study, we compared the structure of the hepatocytes of C57BL/6 mice at the basal level in the untreated control animal, and followed induction with the p-naphthoflavone in the experimental animal. Qualitative analysis of liver sections from control, corn oil-treated mice, and the induced, p-naphthoflavone treated mice were essentially similar with no obvious differences between the two groups.