Ocinmm grastissimuin extract inhibits stimulated acid secretion by Carbachol and induces gastric mucus secretion

Abstract

In this study, the effects of cthanol extract of Ocinmm gratissimum (EEOG) on both basal and stimulated gastric acid secretion and gastric mucus secretion were investigated in Albino rats treated with the extract. Four groups of animals were used. Sub-group 1A serves as control. Animals in Group ?.A, 3B and 4B were pretreated with 200mg/kg of (EEOG) for 1, 7 and 14 days respectively. Basal gastric effluents were collected from all the groups of animals at intervals of lOmins for 60mins. Thereafter, Subgroups 1 A, 2A, 3A and 4A were administered with 50/x/kg b.w. of carbachol (i.p.) intraperitonialy and effluents collected. Animals in Sub-group B were used for gastric mucus study. Carbachol stimulates gastric acid secretion in animals pretreated with the extract for 1, 7 and 14 days. 50-400 mg/kg b.w. doses of the extract significantly increase gastric mucus secretion. These results indicate the mechanism of anti-ulcer activity of the extract may be due to stimulation of gastric mucus secretion amongst pathways