Sensitivity of Plasmodium falciparum to chloroquine, amodiaquine and mefloquine in Ibadan, Nigeria

SIMOOYA, O. O.; ADEROUNMUt, A. FADEKE; SALAKO, L. A.

Please use this identifier to cite or link to this item: http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2032

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DC Field	Value	Language
dc.contributor.author	SIMOOYA, O. O.	-
dc.contributor.author	ADEROUNMUt, A. FADEKE	-
dc.contributor.author	SALAKO, L. A.	-
dc.date.accessioned	2024-07-01T11:33:52Z	-
dc.date.available	2024-07-01T11:33:52Z	-
dc.date.issued	1988	-
dc.identifier.citation	Afr. J. Med. med Sci (1988) 17.3-7	en_US
dc.identifier.issn	1116-4077	-
dc.identifier.uri	http://adhlui.com.ui.edu.ng/jspui/handle/123456789/2032	-
dc.description	Article	en_US
dc.description.abstract	The schizontocidal effect of chloroquine was compared to that of amodiaquine in vivo and mefloquine in vitro. In the in-vivo study, 32 patients were randomly given chloroquine whilst 29 received amodiaquine. The mean parasite clearance time was 2.5 days for chloroquine and 2.4 days for amodiaquine. These times were not significantly different. The cure rate in both groups up to day 14 was 100%. In the in-vitro study, three isolates of Plasmodium falciparum were compared for their sensitivity to chloroquine and mefloquine. In all three isolates schizogony was inhibited at a concentration of 0.8 x 10"6 mol/l of either drug. It was concluded that chloroquine is still an effective schizontocidc and should remain the drug of choice for the treatment of P. falciparum in the Ibadan area.	en_US
dc.description.sponsorship	COLLEGE OF MEDICINE	en_US
dc.language.iso	en	en_US
dc.publisher	BLACKWELL SCIENTIFIC PUBLICATIONS	en_US
dc.subject	mefloquime	en_US
dc.subject	patients	en_US
dc.subject	parasite	en_US
dc.subject	amodiaquine	en_US
dc.subject	schizontocidal effect of chloroquine	en_US
dc.subject	Plasmodium falciparum	en_US
dc.title	Sensitivity of Plasmodium falciparum to chloroquine, amodiaquine and mefloquine in Ibadan, Nigeria	en_US
dc.type	Article	en_US
Appears in Collections:	African Journal of Medicine and Medical Sciences

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