Protective ability of locally extracted Protein A against pathogenic organisms

Abstract

This study was conducted to find out the ability of Protein A obtained from a local isolate of Staphylococcus aureus to protect rats against infection by pathogenic organisms. A good amount (5000µg) of Protein A was extracted from a small quantity (approximately 40g) of Staphylococcus aureus culture using lysostaphin technique. This extract was found to have protective property against pathogenic Escherichia coli and Pseudomonas aeruginosa in rats even at a low concentration of 50µg. The crude Protein A extract also compared favorable with imported standard Protein A in the study.